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November 25, 2005

The amyloid beta ptoein may not be the only monster, AlzClub reader says

"The amyloid beta ptoein may not be the only monster, or even may not be the monster at all. My reasearch showed that reducing the amyloid precursor protein expression using antisense did improve the memory in mice considerably. If amyloid peptide has no role to play in AD, how would we explain the famous mutations in APP that enhance the accumulation of betaprotein also cause AD?. I think, formation of insoluble plaques may be the way in which the brain fights a soluble toxic agent or it indirectly generates. It is almost impossible to get a few dollars for alternate studies any way. I have lipid theory and complement theory, both were shot in their heart, dispite reasonable evidence I presented. If some one who sees this letter gives me a lead to which agency I may approach for few dollars to conduct AD research that involves other theories, I would be obliged."

Vijaya B. Kumar, Ph.D.

Source: Reader comment. Wall Street Journal Covers Alzheimer's Research. AlzClub.Org (16 November 2005) [FullText]

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