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February 01, 2008
Paper Alert by Alzforum: ABCA1 Protects Against Amyloid Deposition
ABCA1 seems crucial for loading ApoE with lipid and loss of the transporter leads to reduced levels of ApoE, but not amyloid, in the brain (see ARF related news story). These latest results support the idea that the lipidation status of ApoE is intimately linked with its effect on Aβ processing and aggregation. The data “support the conclusions that increased ABCA1-mediated lipidation of apoE in the CNS can reduce amyloid burden and that increasing ABCA1 function may have a therapeutic effect on AD,” write the authors.—Tom Fagan.
Reference:Wahrle SE, Jiang H, Parsadanian M, Kim J, Li A, Knoten A, Jain S, Hirsch-Reinshagen V, Wellington CL, Bales KR, Paul SM, Holtzman DM. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J. Clin. Invest. 2008 January 17 online. Full Text at J Clin Investigation Abstract
Source: Alzforum research news (22 January 2008) [FullText and comments]
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