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July 09, 2006
Nature News Says Alzheimer's Field is a Mafia, Implies Alzheimer's International Conference to be Biased in Favor of Amyloid Dogma
Excerpt: "In the Church of the Holy Amyloid, the reigning deity is a 42-amino acid protein, thought to be the key to the mysteries that underlie Alzheimer disease. Amyloid has many believers and like any good religion, a few staunch heretics who question its supremacy. As flippant as this might sound, this is how some see the dominance of the amyloid-beta protein in Alzheimer disease research. For more than a decade, many scientists have believed that the protein triggers a series of steps dubbed the amyloid cascade that leads to the memory loss and dementia in those afflicted with Alzheimer disease. Every aspect of the field reflects this theory's dominance... But some researchers in the community and a few outside it say that those who believe the amyloid cascade hypothesis have unwisely pushed it, perhaps to the detriment of the whole field. ...Even among those who are more measured in their criticisms, the phrase "all of your eggs in one basket" comes up with startling frequency. These scientists say that despite many unexplained aspects, there is a disproportionate amount of attention paid to the amyloid hypothesis that has prevented other ideas from flourishing. With such a complex disease, they warn, it is foolhardy, perhaps even dangerous, to focus exclusively on one theory... If you don't endorse the amyloid hypothesis and actively work on some aspect related to it, some say, it's difficult to win funds, publish papers or present at conferences. To have any credibility, people have to prove that their idea has some merit. But without funds and some element of receptiveness, that's hard to do, notes Larry Goldstein, professor of molecular medicine at the University of California in San Diego. "There's a certain catch-22, I think," Goldstein says. "I'm not trying to insult these folks, but it's quite a mafia if you really look at the field..."
Source: Apoorva Mandavilli, senior news editor of Nature Medicine. Amyloid code. Nature Medicine, Nature News (28 June 2006) [FullText]
Source: Apoorva Mandavilli, senior news editor of Nature Medicine. Amyloid code. Nature Medicine, Nature News (28 June 2006) [FullText]
posted by Dr. Koudinov @ 9.7.06
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