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April 05, 2006
Two New Drugs for the Treatment of Alzheimer's Disease are Expected to Enter the Market by 2008
- Currently, the most promising diagnostic agent for Alzheimer's disease (AD) is Pittsburgh Compound B, an A(beta)-amyloid imaging agent in development by GE Healthcare. We expect this agent to reach the market by 2011 and to increase the number of diagnosed and drug-treated patients by 2013.
- Several drugs are in development for treatment of AD; we expect two of these to reach the market by 2008. To be most effective, these treatments must be initiated in patients as soon as possible.
- Besides elucidating the progression of AD, a biomarker for AD would increase drug-treatment rates and therefore increase revenues for drug companies with marketed AD therapies. The increase in drug-treatment rates would result from earlier diagnosis of more patients and, consequently, longer durations of disease treatment. However, if no biomarker becomes available during our study period, we estimate that AD drugs will not attain their full market potential.
- The potential for sales of an AD diagnostic agent could be significant, due to the increasing prevalence of the disease and the potential for a diagnostic agent to command better pricing than a traditional diagnostic, given the large unmet need.
- A diagnostic agent approved by the FDA as an efficacy end point could dramatically grow the market potential for a disease-modifying drug by increasing diagnosis rates, drug-treatment rates, and duration of therapy. A therapeutic agent that demonstrated disease modification based on a biomarker could command a significant premium.
- An AD biomarker will greatly reduce costs associated with drug development by enabling selection of a more homogeneous patient population for smaller, more cost-effective clinical trials. A biomarker will also accelerate drug development by facilitating decisions as to whether to pursue or abandon agents in the early stages of clinical development.
Currently, Alzheimers disease (AD) is diagnosed based on patient clinical history and exclusion of other neurological disorders. Because early signs of AD are hard to distinguish from normal signs of aging, most patients are not diagnosed until neuronal damage is extensive. A diagnostic marker would enable physicians to diagnose more AD patients earlier and begin drug treatment when it could be most effective. The AD therapeutics market would also benefit: early diagnosis and treatment translates to more therapy sales over longer treatment periods.
In this Decision Resources report, we review AD diagnostic markers currently in use and in development, the main players in the AD diagnostics arena, and the impact that these markers will have on the U.S. AD market over the next ten years.
Topics Covered
-- Introduction
-- Pathophysiology of Alzheimers Disease
-- Value of a Biomarker for Alzheimers Disease
-- Necessary Attributes of Alzheimers Disease Biochemical Markers
-- Emerging Imaging Agents for Diagnosis of Alzheimers Disease
-- Key Players in Alzheimers Disease Diagnostics
-- Market Implications
-- Outlook
-- Figure 1. Amyloid Plaques and Neurofibrillary Tangles in Alzheimer's Disease
-- Figure 2. The Bio-Barcode Assay
-- Figure 3. Duration of Therapy for Alzheimer's Disease
-- Figure 4. Potential Sales Scenarios for an Alzheimer's Disease Therapy
-- Figure 5. Major Events the Alzheimer's Disease Market, US
-- Table 1. Current Markers Used in the Diagnosis of Alzheimer's Disease
-- Table 2. Select Companies Pursuing Alzheimer's Disease Diagnostics
-- Table 3. Select Collaborations in Alzheimer's Disease Diagnostics
Companies Mentioned
-- Applied Neurosolutions
-- Aspect Medical Systems
-- AstraZeneca
-- Athena Diagnostics
-- Avid Radiopharmaceuticals
-- BioMerieux
-- Celera Diagnostics
-- deCode Diagnostics
-- Eisai
-- Dyax
-- Innogenetics
-- Kronos Science Laboratories
-- Takeda Chemical Industries
-- Izalex
-- National Institute on Aging (NIA)
-- Perlegen Sciences
-- Pfizer
-- Power3 Medical ProductsProteome Sciences
-- Roche Diagnostics
-- Translational Genomics Research Institute
For more information visit www.researchandmarkets.com
Source: Business Wire (4 April 2006) [FullText]
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