Alzheimer's Club

"The first study of the effects of testosterone on mood, behavior and psychological health in men with mild Alzheimer's disease finds significant improvements in quality of life, as assessed by caregivers.

Led by neuroscientists at the University of California, Los Angeles, Alzheimer's Disease Research Center and detailed in an early online release of the peer-reviewed journal Archives of Neurology, the double-blind, placebo-controlled study used caregiver assessments to evaluate quality of life and used a battery of tests administered by clinicians to evaluate cognitive skills.

Alzheimer's patients treated with testosterone showed significant improvement on a quality-of-life instrument that encompasses memory, interpersonal relationships, physical health, energy, living situation and overall well-being, compared with patients who received a placebo. However, researchers found no significant differences in memory or other cognitive skills as assessed by tests administered by clinicians.

"The results suggest that testosterone replacement therapy holds potential for improving the quality of life of Alzheimer's patients and merits further testing with a larger group of patients and with a longer treatment period," says Po-Haong Lu, Psy.D., the study's lead author and assistant clinical professor of neurology at the research center and the David Geffen School of Medicine at UCLA.

Alzheimer's disease, which causes memory loss, behavior changes and difficulties with thinking, affects an estimated 4 million Americans.

The 24-week study included 16 male patients diagnosed with mild Alzheimer's disease and 22 healthy male control subjects. Each group was randomly subdivided into two treatment arms. One group received daily testosterone treatment in the form of hydroalcoholic gel (75 mg) and the other received a gel with no active medication.

The research team assessed subjects' cognitive function, neuropsychiatric symptoms, global functioning and quality of life. Among patients with the disease, the testosterone-treated group had significantly greater improvements in the scores on the caregiver version of the quality-of-life scale than those who received the placebo. No statistically significant differences were seen in cognitive or other scores at the end of the study, though numerically greater improvement or less decline in measures of visual-spatial abilities were found in the group treated with testosterone.

In the healthy control group, a nonsignificant trend toward greater improvement in self-rated quality of life was observed in the testosterone-treated group compared with placebo treatment."

Source: Testosterone improves life with Alzheimer's. myDNA News. (14 December 2005) [FullText]