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August 13, 2005
Elevated Insulin My Contribute to Alzheimer's, Archives of Neurology Article says
"Elevated insulin levels may contribute to the development of Alzheimer's disease, and investigators hope this new finding will lead to more effective treatment strategies, according to a report in the August 8 issue of the Archives of Neurology. Researchers at the University of Washington in Seattle raised blood insulin levels in 16 healthy older adult volunteers and then measured changes in the volunteers' levels of inflammatory markers and beta-amyloid (a protein associated with Alzheimer's disease) in their cerebrospinal fluid and plasma.
"Moderate peripheral hyperinsulinaemia (increased levels of insulin) provoked striking increases in CNS (central nervous system) inflammatory markers," the study authors wrote. "Our findings suggest that insulin-resistant conditions such as diabetes mellitus and hypertension may increase the risk for Alzheimer's disease, in part through insulin-induced inflammation." The research team concluded: "Although this model has obvious relevance for diabetes mellitus, hyperinsulinaemia and insulin resistance are widespread conditions that affect many nondiabetic adults with obesity, impaired glucose tolerance, cardiovascular disease and hypertension. Our results provide a cautionary note for the current epidemic of such conditions, which, in the context of an ageing population, may provoke a dramatic increase in the prevalence of Alzheimer's disease.""
Source: Insulin, Alzheimer's link. Health24.com (South Africa) (10 August 2005) [FullText]
"Moderate peripheral hyperinsulinaemia (increased levels of insulin) provoked striking increases in CNS (central nervous system) inflammatory markers," the study authors wrote. "Our findings suggest that insulin-resistant conditions such as diabetes mellitus and hypertension may increase the risk for Alzheimer's disease, in part through insulin-induced inflammation." The research team concluded: "Although this model has obvious relevance for diabetes mellitus, hyperinsulinaemia and insulin resistance are widespread conditions that affect many nondiabetic adults with obesity, impaired glucose tolerance, cardiovascular disease and hypertension. Our results provide a cautionary note for the current epidemic of such conditions, which, in the context of an ageing population, may provoke a dramatic increase in the prevalence of Alzheimer's disease.""
Source: Insulin, Alzheimer's link. Health24.com (South Africa) (10 August 2005) [FullText]
posted by Dr. Koudinov @ 13.8.05
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