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November 13, 2004
Lay news: Debate over Alzheimer's origins causes divisions
Sharon Begley, "Fevered Debate Over Alzheimer's Origins Causes Deep Divisions" (6 August 2004, The Wall Street Journal, p.B.1)
Abstract: "AS I WROTE last April, there are growing doubts that amyloid is guilty as charged. Autopsies of people with early-stage Alzheimer's show that the tangles form first, before plaques, in brain regions initially affected by the disease. "If you look at the evidence, it's the tangles that cause neuronal degeneration, and they come first, before the amyloid," says neurologist Patrick McGeer of the University of British Columbia, Vancouver, who was awarded one of the Alzheimer's Association's top scientific prizes at the meeting.
Another problem for the amyloid dogma is that "almost all aged brains have extensive amyloid deposition, even in people who die with no symptoms of Alzheimer's," says neurologist Peter Davies of the Albert Einstein College of Medicine in the Bronx. Worse, adds neurobiologist Nikolaos Robakis of Mount Sinai School of Medicine, New York City, autopsies of the brains of Alzheimer's victims show that "plaques don't correlate with neuronal death. The amyloid is here and the dead neurons are somewhere else."
No existing drug stops, let alone reverses, the inexorable cognitive and memory decline of Alzheimer's. The one thing baptists, tauists and apostates agree on is that drugs that prevent the disease will not cure it, and drugs effective against early Alzheimer's won't be the same as those that work against late Alzheimer's. We'll need a whole armamentarium."
[Free FullText at SFC]
Abstract: "AS I WROTE last April, there are growing doubts that amyloid is guilty as charged. Autopsies of people with early-stage Alzheimer's show that the tangles form first, before plaques, in brain regions initially affected by the disease. "If you look at the evidence, it's the tangles that cause neuronal degeneration, and they come first, before the amyloid," says neurologist Patrick McGeer of the University of British Columbia, Vancouver, who was awarded one of the Alzheimer's Association's top scientific prizes at the meeting.
Another problem for the amyloid dogma is that "almost all aged brains have extensive amyloid deposition, even in people who die with no symptoms of Alzheimer's," says neurologist Peter Davies of the Albert Einstein College of Medicine in the Bronx. Worse, adds neurobiologist Nikolaos Robakis of Mount Sinai School of Medicine, New York City, autopsies of the brains of Alzheimer's victims show that "plaques don't correlate with neuronal death. The amyloid is here and the dead neurons are somewhere else."
No existing drug stops, let alone reverses, the inexorable cognitive and memory decline of Alzheimer's. The one thing baptists, tauists and apostates agree on is that drugs that prevent the disease will not cure it, and drugs effective against early Alzheimer's won't be the same as those that work against late Alzheimer's. We'll need a whole armamentarium."
[Free FullText at SFC]
posted by Dr. Koudinov @ 13.11.04
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