 eLetters
(click on arrows to read letters): |
Papers under discussion: |
Amyloid beta road show, or Has the lure of profits corrupted Alzheimer’s
neuroscience?
Alexei R. Koudinov
Published online 5 August 2003; Current
hit parade: 1739
|
Monsonego A et al.
Increased T cell reactivity to amyloid b
protein
in older humans and patients with Alzheimer disease.
J Clin Invest. 1 Aug 2003 112: 415-22
[ PubMed
] [ Abstract
]
Eriksen JL et al.
NSAIDs and enantiomers of flurbiprofen target gamma-secretase
and lower Abeta42 in vivo.
J Clin Invest. 1 Aug 2003 112: 440-9
[ PubMed
] [ Abstract
]
Cirrito JR, Holtzman DM.
Amyloid b and Alzheimer disease
therapeutics: the devil may be in the detail. J Clin Invest. 1 Aug
2003 112: 321-3
[ PubMed
] [ Abstract
].
|
Cholesterol and Alzheimer's: is amyloid beta a cause or consequence
of the disease?
Alexei R. Koudinov
(Published online 30 July 2003; Current
hit parade: 703)
Original ( 321 words 5 citations) letter was first electronically
submitted on July 22, 2003 as correspondence to Neurology. It was then
rejected on July 30, 2003. Neurology rejection letter stated: We
do not think the letter warrants publication as it does not add any substantial
contribution to the literature.
|
Pappolla MA et al.
Mild hypercholesterolemia is an early risk factor for
the development of Alzheimer amyloid pathology.
Neurology 22 July 2003 61: 199-205.
[ PubMed
] [ Full
Text ] [NoL
Noteworthy]
|
Amyloid beta and Alzheimer's disease: an endpoint relation?
Alexei R. Koudinov
Published online 13 July 2003; Current
hit parade: 678
|
Sunderland T et al.
Decreased b-Amyloid 1-42 and
Increased Tau Levels in Cerebrospinal Fluid of Patients With Alzheimer
Disease.
JAMA 2003 289: 2094-103.
[ PubMed
]
Ronald and Nancy Reagan Research Institute of the Alzheimer's
Association and the NIA working group: consensus report of the working
group on: "molecular and biochemical markers of Alzheimer's disease.
Neurobiol Aging 1998 19: 109-116
[Erratum in: Neurobiol Aging. 1998 19: 285]
[ PubMed
] [ Erratum
FullText ].
Thies B, Truschke E, Morrison-Bogorad M, Hodes RJ.
Consensus report of the Working Group on: molecular and
biochemical markers of Alzheimer's disease. Letter to the editor.
Neurobiol Aging. 1999 20: 247
[ PubMed
] [ FullText
]
|
Open letter to Donald Kennedy, Science Editor-in-Chief: AAAS, Science,
Alzheimer’s disease and academic dishonesty.
On August 8, 2003 I noticed that
this letter was removed from SAGE KE. Unhappy to know? Then ask
SAGE KE editor when it will be back at SAGE KE. Meanwhile the original
letter is available at this link and at Science SAGE KE logo above.
Alexei R. Koudinov
Published online 16 June 2003; Current
hit parade: 1192
|
Bloom FE.
Presidential address. Science as a way of life: perplexities
of a physician-scientist.
Science. 13 June 2003 300, 1680-5.
[ Full
Text ] [ AAAS
coverage ] [ PubMed
]
|
22 May 2003 Neuron article on Alzheimer's : 'valid research' or a
'drug company propaganda'?
Alexei R. Koudinov
(Submitted/published online 31 May / 1 June 2003; Current
hit parade: 1899)
Hasta la vista, amyloid cascade hypothesis, OR will academic dishonesty
yield Alzheimer's cure?
Alexei R. Koudinov
Published online 26 May 2003; Current
hit parade: 1203
|
Hock C, et al.
Report: Antibodies against ß-Amyloid Slow Cognitive
Decline in Alzheimer's Disease
Neuron 22 May 2003 38, 547-554
[ Abstract
at Neuron ] [ PubMed
]
Winblad B, Blum KI.
Preview: Hints of a Therapeutic Vaccine for Alzheimer's?
Neuron 22 May 2003 38, 517-518
[ Abstract
at Neuron ] [ PubMed
]
|
Alzheimer's amyloid beta oligomers versus lipoprotein Ab.
Alexei R. Koudinov
Published online 1 May 2003; Current
hit parade: 631
|
Kayed R, et al.
Common structure of soluble amyloid oligomers implies
common mechanism of pathogenesis.
Science. 18 April 2003 300, 486-489.
[ Full
Text ] [ SAGE
KE ] [ PubMed
]
|
Correspondence
with Neuron editorial office (August 2002)
( Click on the title above to open
an Acrobat .PDF imprint of the letter. Acrobat
reader required )
Alexei R. Koudinov
(A. Koudinov correspondence with Neuron (August 2002,
two items) on the conflict of interest between Dennis J. Selkoe, M.D. service
as Elan corporation director and academic service as Neuron Editorial board
member, and an author of an article missing competing interest disclosure) |
Selkoe DJ.
Clearing the brain's amyloid cobwebs.
Neuron. 25 Oct 2001 32, 177
[ Abstract
at Neuron ] [ PubMed
]
|
Correspondence
with Murray Sagsveen (Nov. 2002-March 2003)
( Click on the title above to open
an Acrobat .PDF imprint of the correspondence. Acrobat
reader required )
A. Koudinov correspondence with AAN (13 Nov. 2002 - 26
March 2003, eight items) on the conflict of interest between Dennis J.
Selkoe, M.D., service as a chairperson for Potamkin Prize for Alzheimer's
disease, Pick's disease and related disorders and D. Selkoe service as
Elan corporation director
( Become public on 27 March 2003; July 1, 2003 hit parade:
225)
Also see:
A. Koudinov Feb 28, 2003 letter
to Science Editor-in-Chief . |
| AMERICAN ACADEMY OF NEUROLOGY POTAMKIN PRIZE |
Murray G. Sagsveen, General Counsel and Associate Executive
Director,
American Academy of Neurology (AAN)
Rosenberg RN.
The Potamkin Prize for Pick's, Alzheimer's Disease and
Related Disorders.
AAN web site (last viewed 26 March 2003)
[ Original
.DOC file ] [ HTML
cached version ].
The Potamkin Prize for Research in Pick's, Alzheimer's
and Related disorders. The winner history 2002 edition
AAN web site (last viewed 26 March 2003)
[ Original
.DOC file ] [ HTML
cached version ].
News release: 2002 Potamkin Prize Recognizes The Ground-Breaking
Work Of Alzheimer?s Disease Researchers In Germany, Belgium
AAN web site (Published 13 April 2002; last viewed
26 March 2003)
[ Original
.DOC file ] [ HTML
cached version ].
Press release: Christian Haass, PhD, 2002 Potamkin Prize
co-recipient
AAN web site (last viewed 26 March 2003)
[ Original
Acrobat .PDF file ] [ HTML
cached version ].
2003 Potamkin Prize Shared By Two Researchers.
Medica.de web site (13 March 2003)
[ Full
Text ] |
See
a BIG picture.
Alexei R. Koudinov, M.D., Ph.D.
(published online 22 November 2002)
|
Kamenetz F. et al.
APP Processing and Synaptic Function.
Neuron 27 March 2003 37: 925-937.
[ Abstract/FullText
] [ AlzForum News
Report ]
| SOCIETY for NEUROSCIENCE ABSTRACTS
2000 |
Kamenetz F. et al.
Activity dependent secretion of b-amyloid:
roles of b-amyloid in synaptic transmission.
Soc Neurosci Abstr 2000 26: 491.
[ Abstract
at Scholarone ]
Koudinova NV. et al.
Amyloid beta, neural lipids, cholesterol and Alzheimer's
disease.
Neurobiol Lipids 4 March 2003 1: 6
[ Free
FullText ]
Koudinov AR and Koudinova NV
Amyloid beta protein restores hippocampal long-term potentiation:
a central role for cholesterol?
Neurobiol Lipids 2003 1: 8 In
Press
[ Abstract
]
Lazarov O. et al.
Evidence that synaptically released b-amyloid
accumulates as extracellular deposits in the hippocampus of transgenic
mice.
J Neurosci 15 Nov 2002 22: 9785-93.
[ PubMed
] |
Alzheimer's disease vaccine danger: take it straightforward, not
double-edged
Alexei R. Koudinov
(Submitted/published online 22/23 March 2003; Current
hit parade: 1215) |
Greenberg SM, Bacskai BJ, Hyman BT.
Alzheimer disease's double-edged vaccine.
Nature Medicine (17 March 2003) doi:10.1038/nm847
[ FullText].
Nicoll JAR et al.
Neuropathology of Alzheimer's disease after immunization
with amyloid-beta peptide: a case report.
Nature Medicine (17 March 2003) doi:10.1038/nm840
[ FullText
]
Check E.
Autopsy of inflamed brain points to vaccine dangers.
Nature News Service (17 March 2003)
[ FullText
].
|
Open letter to Public Citizen's Health Research Group on Alzheimer's
disease research.
Alexei R. Koudinov
SAGE KE letter published online 21 February 2003. BMJ
letter first submitted 17 February; re-submitted 20 February; published
27 February 2003
Joint current hit parade:
|
Laura Helmuth.
NSAIDS for prevention? Protecting the brain while killing
pain?
Science 23 August 2003 297: 1262
[ Full
Text ] [ PubMed
] [ Correction
]
Laura Helmuth.
New therapies. New Alzheimer's treatments that may ease
the mind.
Science 23 August 2003 297: 1260
[ Full
Text ] [ PubMed
]
Also see:
Barbehenn E, Lurie P, Wolfe SM.
Letter to HHS Secretary Tommy Thompson that raises ethical
concerns about the “Alzheimer’s Disease Anti-Inflammatory Prevention Trial”
(ADAPT) (HRG Publication #1637)
Public Citizen publications. 4 September 2002
[ FullText
] |
Do
not underscore the epidemics of the business, too.
( Click on the title above to open
an Acrobat .PDF imprint of the submitted dEbate letter. Acrobat
reader required )
Alexei R. Koudinov
Submitted on 31 Jan 2003 as Science dEbate letter.
Rejected by Science on 7 Feb 2003; become public on 20
March 2003; July 1 2003 hit parade: 116
The rejection letter stated:
"We will not be publishing your dEbate submission,
as we feel that it simply reiterates previous comments you have made
about Dr. Selkoe." |
Donald Kennedy
Editorial: An epidemic of politics.
Science 31 Jan 2003 299(5607): 625
[ PubMed
][ Abstract/FullText
].
|
Does Rotterdam study question the link between fat and dementia?
Alexei R. Koudinov
(submitted online 27 December 2002/Published online 15
January 2003; Current hit parade: 500)
|
Engelhart MJ et al.
Diet and risk of dementia: Does fat matter? The Rotterdam
Study.
Neurology 2002 59: 1915-21.
[ PubMed
] [ Full
Text ] [ ARF
News] [NoL
Noteworthy]
|
|
YEAR 2002
|
| eLetters
(click on arrows to read letters): |
Papers under discussion: |
Amyloid was never clearly implicated in Alzheimer's disease, so look
at Ab from a different angle.
Alexei R. Koudinov
(submitted/published online 26/30 November 2002; Current
hit parade: )
The early version of this BMJ letter was first
submitted (20 Nov 2002, and then rejected) to J. Clin. Invest. as
eLetter to editor for article by D. Selkoe cited to the right.
|
Selkoe DJ.
Alzheimer's disease is a synaptic failure.
Science 2002 Oct 25;298(5594): 789
[ PubMed
] [ Correction
].
Golde TE.
Alzheimer disease therapy: Can the amyloid cascade be
halted?
J Clin Invest 2003 Jan;111(1): 11
[ PubMed
] [ FullText
].
Selkoe DJ.
Deciphering the genesis and fate of amyloid beta-protein
yields novel therapies for Alzheimer disease.
J Clin Invest 2002 Nov;110(10): 1375
[ PubMed
].
Wolfe MS.
Therapeutic strategies for Alzheimer's disease.
Nature Rev Drug Discov 2002 Nov; 1(11):
859
[ PubMed
]
Haass C.
New hope for Alzheimer disease vaccine.
Nature Medicine 2002 Nov; 8(11): 1195
[ PubMed
].
Citron M.
Alzheimer's disease: treatments in discovery and development.
Nature Neuroscience 2002 Nov; 5 (Suppl
1): 1055
[ PubMed
].
Selkoe DJ, Schenk D.
Alzheimer's Disease: Molecular Understanding Predicts
Amyloid-Based Therapeutics.
Annu Rev Pharmacol Toxicol 2002 Oct 4
[ PubMed]
Colin L Masters and Konrad Beyreuther
Clinical review: Science, medicine, and the future: Alzheimer's
disease.
BMJ 7 February 1998 316: 446
[ Full
Text ]
|
Ethical Conundrums : An Alzheimer's case.
Alexei R. Koudinov
Also, see the .PDF
imprint of the original dEbate letter submitted to Science, and then
rejected.
(submitted/published online 8/12 September 2002; Current
hit parade:
Amyloid hypothesis: summer 2002 and 8th International Conference
on Alzheimer’s disease update.
Alexei R. Koudinov & Natalia V. Koudinova
(submitted/resubmitted online 29/30 July 2002; published
online 31 July 2002; Current hit parade: )
|
Ready T.
Science for Sale : A Harvard researcher stands to profit
from a product he "independently" reviewed for the National Institutes
of Health.
The Boston Phoenix, Published 29 April 1999
[ Full
Text ]
Crowley D.
Elan Alzheimer's expert in pre-slump share sale
The Sunday Business Post, Published 18 August
2002
[ Full
Text ]
John Hardy, Dennis Selkoe.
The Amyloid Hypothesis of Alzheimer's Disease: Progress
and Problems on the Road to Therapeutics.
Science 19 July 2002 297: 353
[ Full
Text ] [ PubMed
] [ Correction
]
Rosenberg RN.
Explaining the Cause of the Amyloid Burden in Alzheimer
Disease.
Arch Neurol 2002 59:
1439-43
[ PubMed
] [ Full
Text ]
|
Alzheimer's disease and amyloid beta protein.
Alexei R. Koudinov, Mark A. Smith, George Perry & Natalia V. Koudinova
(submitted/published online 14/25 June 2002; Current
hit parade: 3142)
|
J. Paul Taylor, John Hardy, Kenneth H. Fischbeck.
Toxic Proteins in Neurodegenerative Disease.
Science 14 June 2002 296: 1991
[ Full
Text ] [ PubMed
]
Walsh DM, Klyubin I, Fadeeva JV, et al.
Naturally secreted oligomers of amyloid beta protein
potently inhibit hippocampal long-term potentiation in vivo.
Nature April 2002 416: 535-539
[ PubMed
] [ Alz
Forum news story ] |
| Expert readers feedback on the above letters by Koudinov
et
al:
"... thanks for your making another strong statement
about the realities involving the amyloid hypothesis..."
"...Thanks for pointing this out."
"Excellent letter. I totally agree with your position.
Hopefully in the near future scientists that are part of study sections
scoring grants will value the importance of research projects characterizing
the normal physiological role(s) of amyloid beta and other fragments of
APP."
"I have been in this field for over 15 years and I
agree with you that the amyloid theory of AD is far from clear... We clearly
need a better theory for explaining this disorder"
"Finally, after 15 years of "bad" amyloid maybe
somebody will look at the function..."
"I agree whole heartily
with your letter to Science concerning Alzheimer's disease and the amyloid
beta protein. It is amazing how this field has been led down the "amyloid
hypothesis" trail to the exclusion of other viable hypotheses. If you don't
go along with the amyloid dogma, you have difficulty publishing and extreme
difficulty being funded. The anti-intellectual, anti-science mentality
displayed by many in this field has slowed progress to a crawl. This is
a shame."
"...Many thanks for all the information... I was going
to do an article more than a year ago saying that a clinical trial of A-beta
vaccination was too hazardous to try, but never got around to it. Then
the disaster that many of us predicted would result came to pass. I thought
common sense would then prevail and this whole idea would be abandoned.
But as you have pointed out, the dogma is too strong to be dropped, and
now it is the application, and not a faulty theory that is being blamed.
More AD cases are in danger..."
|
Alzheimer’s amyloid dogma. A time for change
Alexei R. Koudinov, Mark A. Smith, George Perry, Natalia V. Koudinova
(submitted/published online 21 June 2002; Current
hit parade: 864) |
Lawrence I Golbe
Neurodegeneration in the age of molecular biology.
BMJ 22 June 2002 324: 1467
[ Full
Text ]
J. Paul Taylor, John Hardy, Kenneth H. Fischbeck.
Toxic Proteins in Neurodegenerative Disease.
Science 14 June 2002 296: 1991
[ Full
Text ] [ PubMed
] |
Amyloid hypothesis, synaptic function, and Alzheimer’s disease,
or
Beware: the dogma is revitalized.
Alexei R. Koudinov, M.D., Ph.D., &
Natalia V. Koudinova, M.D., Ph.D.
(Submitted/published online 14/15 May 2002; First submitted
to Nature on April 12 and April 24, 2002; Current
hit parade: 1993)
Correspondence
with Nature editorial office (April-December 2002)
( Click on the title above to open
an Acrobat .PDF imprint of the letter. Acrobat
reader required )
Alexei R. Koudinov
(A. Koudinov correspondence with Nature on the non-disclosure
of Dennis J. Selkoe conflict of interest (as Elan corporation director)
in the Nature article under discussion. |
Walsh DM, Klyubin I, Fadeeva JV, et al.
Naturally secreted oligomers of amyloid beta protein
potently inhibit hippocampal long-term potentiation in vivo.
Nature April 2002 416: 535-539
[ PubMed
] [ Alz
Forum news story ] [ Nature
news ] [ Disclaimer
] |
Alzheimer’s anti-amyloid vaccination and statins: two approaches,
one dogma. The time for change.
Alexei R. Koudinov, M.D., Ph.D., &
Natalia V. Koudinova, M.D., Ph.D.
(Submitted/published online 20 March 2002; Current
hit parade: 2774) |
Check E.
Nerve inflammation halts trial for Alzheimer's drug.
Nature 31 Jan 2002 415: 462
[ PubMed
] [ Alz
Forum discussion ]
Wiebe S and Nicolle MW
CLINICAL REVIEW
Recent developments: Recent developments in neurology
BMJ 16 March 2002 324: 656-660
[ PubMed
] [ Full Text
] |
(a .PDF imprint of submitted letter. Acrobat
reader required)
Alzheimer's amyloid beta: is it really bad.
Alexei R. Koudinov, Ulrike Beisiegel & Natalia V. Koudinova.
(submitted online 19 March 2001; originally e-submitted
to Science on March 13, 2001)
|
Marx J.
Alzheimer's disease: bad for the heart, bad for the mind?
Science (19 October 2001) 294: 508-509
[ PubMed]
[ Full
Text ]
Simons M, Keller P, Dichgans J, Schulz JB.
Cholesterol and Alzheimer's disease: Is there a link?
Neurology 2001 57: 1089-93.
[ PubMed
] [ Full
Text ]
Wolozin B.
A fluid connection: Cholesterol and Ab
PNAS 2001 98: 5371-3.
[ Full
Text ]
... and a list of other articles on Cholesterol
and amyloid, see the eLetter .PDF imprint for refs.
Also see our BMJ
eLetter of March 2002.
|
Cholesterol homeostasis failure at neuromuscular junctions and CNS
synapses: a unifying cause of synaptic degeneration ?
Alexei R. Koudinov, Natalia V. Koudinova and Ulrike Beisiegel.
(submitted online 20 February 2002/Published online 26
February 2002; Current hit parade: 668)
|
Jaworska-Wilczynska M et al.
Three lipoprotein receptors and cholesterol in inclusion-body
myositis muscle.
Neurology 2002 58: 438-445.
[ PubMed
] [ Full Text
]
Naguib M et al.
Advances in neurobiology of the neuromuscular junction:
implications for the anesthesiologist.
Anesthesiology 2002 96: 202-231.
[ PubMed
] |
Genetics/cardiovascular risk versus environment/Alzheimer's: directions
diverted, cholesterol united
Alexei R. Koudinov, Temirbolat T. Berezov & Natalia V. Koudinova.
(submitted/published online 14 December 2001; updated
2 January 2002; Current hit parade: 1376) |
Day INM & Wilson DI
Science, medicine, and the future: Genetics and cardiovascular
risk.
BMJ 2001 323: 1409.
[ Full
Text ]
Grant WB et al.
Incidence of Dementia and Alzheimer Disease in Nigeria
and the United States.
JAMA 2001 85: 2448.
[ Full
Text ] [ PubMed
] |
High density lipoproteins as hidden imprint of Alzheimer's brain
cholesterol pathology.
Alexei R. Koudinov, Temirbolat T. Berezov & Natalia V. Koudinova.
(submitted online 27 November 2001/published online 12
December 2001)
|
Launer LJ et al.
Cholesterol and neuropathologic markers of Alzheimer's disease: a population-based
autopsy study.
Neurology 2001 57: 1447-52.
[ PubMed
] [ Full
Text ]
Merched A, Xia Y, Visvikis S, Serot JM, Siest G.
Decreased high-density lipoprotein cholesterol and serum apolipoprotein
AI concentrations are highly correlated with the severity of Alzheimer's
disease.
Neurobiol Aging 2000 21: 27-30.
[ PubMed
] |
[ PubMed
]
Cholesterol's role in synapse formation.
Alexei R. Koudinov, M.D., Ph.D., & Natalia V. Koudinova, M.D.,
Ph.D.
(submitted online 2:52 am, Jerusalem time, 9 November
2001; published 22 March 2002; also see .PDF
imprint of the submitted letter) |
Barres BA, Smith SJ.
Cholesterol-Making or Breaking the Synapse.
Science (9 Nov 2001) 294: 1296-1297
[ PubMed
] [ Full
Text ]
Mauch DH et al. CNS Synaptogenesis Promoted by Glia-Derived
Cholesterol.
Science (9 Nov 2001) 294: 1354-1357
[ PubMed
] [ Full
Text ] [ AlzForum
Commentary ] |
Cholesterol, synaptic function and Alzheimer's disease?
Alexei R. Koudinov, M.D., Ph.D., &
Natalia V. Koudinova, M.D., Ph.D.
(published online 16 October 2001; First submitted to
Nature Cell Biology on Ocober 8, 2001 )
|
Puglielli L, et al.
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation
of the amyloid b-peptide.
Nature Cell Biol 2001 10: 905-12 [ PubMed
] [ Full
text ]
Miia Kivipelto et al.
Midlife vascular risk factors and Alzheimer's disease in later life:
longitudinal, population based study
BMJ 2001 322: 1447-51 [ Full
Text ] |
[ PubMed
]
Beware: the link is not simple.
Alexei R. Koudinov, Temirbolat T. Berezov & Natalia V. Koudinova.
(submitted online 1 October 2001/published online 16 October
2001)
|
Marx J.
Alzheimer's disease: bad for the heart, bad for the mind? Science
(19 October 2001) 294: 508-509
[ PubMed
] [ Full
Text ]
Simons M, Keller P, Dichgans J, Schulz JB.
Cholesterol and Alzheimer's disease: Is there a link?
Neurology 2001 57: 1089-93.
[ PubMed
] [ Full
Text ]
Wolozin B.
A fluid connection: Cholesterol and Ab
PNAS 2001 98: 5371-3.
[ Full Text] |
|
LRP: a cholesterol recruitment checkpoint for neuronal structure-functional
plasticity?
Alexei R. Koudinov, M.D., Ph.D., & Natalia V. Koudinova, M.D., Ph.D.
(published online 12 October 2001)
|
Herz J, Strickland DK.
LRP: a multifunctional scavenger and signaling receptor.
J Clin Invest 2001 108: 779-84.
[ PubMed
] [ Full Text
]
Herz J.
The LDL Receptor Gene Family: (Un)Expected Signal Transducers in the
Brain.
Neuron (2001) 29: 571-81.
[ PubMed
] [ Full
Text ]
Herz J.
Lipoprotein receptors: beacons to neurons?
Trends Neurosci 2001 24: 193-5.
[ PubMed
] [ Full
Text ]
|
Alzheimer's pathogenesis: tau and amyloid - a consensus or a challenge
for a third party quest?
[ .PDF
imprint of original Science dEbate eLetter ]
Alexei R. Koudinov, M.D., Ph.D., & Natalia V. Koudinova, M.D., Ph.D.
(published online 4 September 2001/First submitted to
Science as dEbate eLetter to editor on 24 August 2001 |
Gottlieb S.
Scientists propose a new theory for the pathogenesis of Alzheimer's
disease.
BMJ 2001 322: 1085
[ Full
Text ]
Lee VM.
Tauists and baptists united--well almost!
Science 2001 24: 1446-7.
[ PubMed
] [ Full
Text ] |
|
Dementia, cholesterol and the soft science of dietary fat.
Alexei R. Koudinov, M.D., Ph.D., & Natalia V. Koudinova, M.D., Ph.D.
(published online 27 July 2001) |
Gottleib S.
Statins can help prevent dementia.
BMJ 2000 321: 1241a
[ Full
Text ]
Wolozin B.
A fluid connection: Cholesterol and Ab.
PNAS 2001 98: 5371-3.
[ Full Text
]
Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA.
Statins and the risk of dementia.
Lancet 2000 356: 1627-31. [ PubMed
] [ Full
Text ]
Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G.
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl
coenzyme A reductase inhibitors.
Arch Neurol 2000 57: 1439-43.
[ PubMed
] [ Full
Text ]
Taubes G.
The soft science of dietary fat.
Science 2001 291: 2536-45.
[ PubMed
] [ Full
Text ] |
Electronic Public Library of Science?
Alexei R. Koudinov, M.D., Ph.D.
(published online 31 May 2001) |
Mellman I.
Considerations in Creating Online Archives.
Science 2001 292: 51b.
[ Full
Text ] |
|
what is this?
what
is this?
|
